Tumor Growth Ameliorates Cardiac Dysfunction

Heart failure and cancer are the deadliest diseases worldwide. Murine models for cardiac remodeling heart demonstrate that dysfunction promotes progression metastasis spread. Yet, no information is available on whether how tumor affects remodeling. Here, we examined following transverse aortic constriction (TAC) in presence or absence of proliferating cells. We show tumor-bearing mice, two different cell lines, display reduced hypertrophy, lower fibrosis improved contractile function pressure overload induced by TAC surgery. Integrative analysis qRT-PCR, flow cytometry immunofluorescence identified tumor-dependent M1-to-M2 polarization macrophage population as a mediator beneficial effect heart. Importantly, mice lacking functional macrophages fail to improve sustained fibrosis.